Common Promoter Variant in Cyclooxygenase-2 Represses Gene Expression
نویسندگان
چکیده
منابع مشابه
Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.
OBJECTIVE Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease. METHODS AND RESULTS The promoter of COX-2 was screened for variants in healthy subjects by use of polymerase chain reaction-based methods. Promoter activity was ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2002
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000030340.80207.c5